Study of polymorphisms and the methylation status of genes involved in glucocorticosteroid metabolism in patients with asthma and healthy individuals

Abstract

The search for genetic and epigenetic markers of the risk asthma and sensitivity to glucocorticosteroid therapy (GCs) in Russians, Tatars and Bashkirs was performed. It was established that polymorphic variants of genes involved in the metabolism of GCs (NR3C1, CRHR1, GLCCI1, TBXT, FBXL7) affect the features of the development and course of asthma. An analysis of the methylation status of the glucocorticoid-induced transcript 1 GLCCI1 gene revealed an increased level of methylation of the promoter region of the GLCCI1 gene in asthma patients.