Genetic structure of a predisposition to the progression of liver fibrosis of various etiologies

Abstract

We performed the comparative analysis of the genetic structure of a predisposition to the progression of liver fibrosis in HCV-related infections and alcoholic liver disease. Genotype СС rs708272 of CETP gene was associated with cirrhosis in HCV-infected patients (OR=4,08[95%CI:1,69-10,03]; р=0,001). Genotype CG rs12054703 of NUP155 gene was associated with alcoholic liver cirrhosis (OR=1,86[95%CI:1,11-3,13]; р=0,016). Genotype CG rs7590760 of DNMT3A gene had protective effect on the alcoholic liver cirrhosis (OR=0,43[95%CI:0,24-0,78]; р=0,004). The genetic structure of a predisposition to liver cirrhosis is different for chronic hepatitis C virus infection and alcohol-induced liver injury.