Биомаркеры в диагностике и мониторинге лечения болезней клеточных органелл
https://doi.org/10.1234/XXXX-XXXX-2016-7-3-10
Аннотация
Биомаркеры (БМ) - биологические молекулы, отражающие биологический процесс, связанный с клиническими проявлениями заболевания. В данном обзоре представлены современные данные о БМ для трех групп наследственных болезней обмена веществ, относящихся к болезням клеточных органелл - лизосомных болезней накопления (ЛБН), митохондриальных и пероксисомных заболеваний. Ферментная заместительная терапия и другие подходы к лечению уже существуют для ЛБН. Однако, за исключением болезни Гоше, на сегодняшний день известно лишь небольшое число биомаркеров, которые применяются для мониторинга ЛБН и других болезней клеточных органелл. Суммируя литературные данные, следует отметить, что биомаркеры с одной стороны играют важную роль в мониторинге состояния здоровья пациента после создания новых лекарственных препаратов - и, с другой стороны, создают предпосылки для лучшего понимания патогенеза заболеваний и создания новых подходов к их лечению.
Об авторах
Т. Д. Крылова
ФГБНУ Медико-генетический научный центр
Россия
Россия
Т. Ю. Прошлякова
ФГБНУ Медико-генетический научный центр
Россия
Россия
Г. В. Байдакова
ФГБНУ Медико-генетический научный центр
Россия
Россия
Ю. С. Иткис
ФГБНУ Медико-генетический научный центр
Россия
Россия
М. В. Куркина
ФГБНУ Медико-генетический научный центр
Россия
Россия
Е. Ю. Захарова
ФГБНУ Медико-генетический научный центр
Россия
Россия
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Рецензия
Для цитирования:
Крылова Т.Д., Прошлякова Т.Ю., Байдакова Г.В., Иткис Ю.С., Куркина М.В., Захарова Е.Ю. Биомаркеры в диагностике и мониторинге лечения болезней клеточных органелл. Медицинская генетика. 2016;15(7):3-10. https://doi.org/10.1234/XXXX-XXXX-2016-7-3-10
For citation:
Krylova T.D., Proshlyakova T.Y., Baydakova G.V., Itkis Y.S., Kurkina M.V., Zakharova E.Y. Biomarkers in diagnosis and treatment monitoring for the cell organelles diseases. Medical Genetics. 2016;15(7):3-10. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-7-3-10
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