The features of the follicular thyroid cancer genetic determination
Abstract
The complex analysis of the follicular thyroid cancer (FTC) hereditary predisposition with using of genealogical, molecular methods and selection indexes is shown the FTC genetic independence; the distribution in the population and families may well be described by means of a variants polygene model with the importance role of genetic factors in determination of disease (88,8 %) and have allowed to assume the presence of interloci interactions in system of its genetic control; positive selection (Δs =0,041) of FTC and association of mutations Р12А and H449H in 2 and 6 exons of gene PPARγ with follicular structure of neoplasias.
About the Authors
S. A. Shtandel
V.Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine
Russian Federation
Russian Federation
V. V. Khaziev
V.Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine
Russian Federation
Russian Federation
M. E. Sazonov
V.Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine
Russian Federation
Russian Federation
Review
For citations:
Shtandel S.A., Khaziev V.V., Sazonov M.E. The features of the follicular thyroid cancer genetic determination. Medical Genetics. 2020;19(6):100-102. (In Russ.)
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