The role of GC-rich sequences in cell-free DNA in the activation of DNA sensors using the cancer line MCF7 as an example
Abstract
The major research questions: (1) Interaction of TLR9 and AIM2 receptors in MCF7 in response to the action of GC-rich fragments in cell-free DNA (GC-cfDNA); (2) Studying the role of TLR9 and AIM2 receptors in mediating the biological effect of GC-cfDNA on MCF7 cells.
About the Authors
E. M. Malinovskaya
Research Centre for Medical Genetics
Russian Federation
Russian Federation
E. A. Kozhina
Research Centre for Medical Genetics
Russian Federation
Russian Federation
E. S. Ershova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
M. S. Konkova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
V. P. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
P. A. Bobrovsky
Federal Research and Clinical Center of physical-chemical medicine of Federal Medical Biological Agency
Russian Federation
Russian Federation
V. N. Lazarev
Federal Research and Clinical Center of physical-chemical medicine of Federal Medical Biological Agency
Russian Federation
Russian Federation
L. V. Kameneva
Research Centre for Medical Genetics
Russian Federation
Russian Federation
N. N. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
S. V. Kostyuk
Research Centre for Medical Genetics
Russian Federation
Russian Federation
Review
For citations:
Malinovskaya E.M., Kozhina E.A., Ershova E.S., Konkova M.S., Veiko V.P., Bobrovsky P.A., Lazarev V.N., Kameneva L.V., Veiko N.N., Kostyuk S.V. The role of GC-rich sequences in cell-free DNA in the activation of DNA sensors using the cancer line MCF7 as an example. Medical Genetics. 2020;19(6):93-95. (In Russ.)
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