Associations genetic polymorphism of xenobiotic biotransformation enzymes and risk of lung adenocarcinoma

Abstract

In the presented “case-control” study 670 residents of the Kemerovo Region subject to age, sex, ethnicity and smoking status were included. We formed two groups: 1) “Case” - 304 newly diagnosed lung adenocarcinoma patients undergoing a medical treatment in the Kemerovo Regional Oncology Center; 2) “Control” - 366 healthy donors of the Kemerovo Regional Center of Blood Transfusion. Statistical analysis were performed using SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). A significant association obtained between the CYP1A1 (rs4646903Т>С), GSTТ1(del) and lung adenocarcinoma.