Significance of mutations in FGFR3, PIK3CA, TERT and TP53 genes in assessing the prognosis of non-muscle invasive bladder cancer

Abstract

Сurrently available prognostic classifications cannot clearly identify the cases of low and high risk of bladder cancer (BC) progression. We have analyzed the FGFR3, PIK3CA, TERT, and TP53 mutations in 101 BC patients. The correlation of TP53 mutations and absence of mutations in FGFR3, PIK3CA and/or TERT with tumor grade was observed; up to 25% of non-muscle invasive BC cases in low and intermediate risk groups harbor the mutations associated with the disease progression.