Analysis of association of single nucleotide polymorphisms of genes for aryl hydrocarbon receptor signaling pathway with predisposition to uterine fibroids

O. B. Polshvedkina; I. N. Vdovina; S. M. Zaytsev; A. A. Klinovskaya; L. A. Ponomareva; N. V. Ivanova; A. V. Polonikov; O. Yu. Ivanova; O. Yu. Bushueva

Analysis of association of single nucleotide polymorphisms of genes for aryl hydrocarbon receptor signaling pathway with predisposition to uterine fibroids

O. B. Polshvedkina, I. N. Vdovina, S. M. Zaytsev, A. A. Klinovskaya, L. A. Ponomareva, N. V. Ivanova, A. V. Polonikov, O. Yu. Ivanova, O. Yu. Bushueva

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Abstract

A total of 603 females with uterine fibroids and 398 healthy individuals from Central Russia were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) of the aryl hydrocarbon receptor signaling pathway genes (rs2066853 AHR, rs2292596 AHRR, rs2228099 ARNT, rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1800566 NQO1) were done using Taq-Man-based assays. Polymorphisms rs2228099 ARNT (OR=1,58; 95%CI=1,19-2,09) and rs1048943 CYP1A1 (OR=0,59; 95%CI=0,40-0,91) were associated with predisposition to uterine fibroids.

Keywords

uterine fibroids, single nucleotide polymorphism, aryl hydrocarbon receptor pathway, xenobiotic biotransformation

About the Authors

O. B. Polshvedkina

Scientific and clinical multi-center health services to mothers and children name of Z.I. Krugloy
Russian Federation

I. N. Vdovina

Kursk Regional Clinical Hospital” of the Health Committee of the Kursk region
Russian Federation

S. M. Zaytsev