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Analysis of association of single nucleotide polymorphisms of genes for aryl hydrocarbon receptor signaling pathway with predisposition to uterine fibroids

Abstract

A total of 603 females with uterine fibroids and 398 healthy individuals from Central Russia were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) of the aryl hydrocarbon receptor signaling pathway genes (rs2066853 AHR, rs2292596 AHRR, rs2228099 ARNT, rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1800566 NQO1) were done using Taq-Man-based assays. Polymorphisms rs2228099 ARNT (OR=1,58; 95%CI=1,19-2,09) and rs1048943 CYP1A1 (OR=0,59; 95%CI=0,40-0,91) were associated with predisposition to uterine fibroids.

About the Authors

O. B. Polshvedkina
Scientific and clinical multi-center health services to mothers and children name of Z.I. Krugloy
Russian Federation


I. N. Vdovina
Kursk Regional Clinical Hospital” of the Health Committee of the Kursk region
Russian Federation


S. M. Zaytsev
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


A. A. Klinovskaya
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


L. A. Ponomareva
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


N. V. Ivanova
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


A. V. Polonikov
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


O. Yu. Ivanova
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


O. Yu. Bushueva
Kursk State Medical University of the Ministry of Health of Russian Federation
Russian Federation


Review

For citations:


Polshvedkina O.B., Vdovina I.N., Zaytsev S.M., Klinovskaya A.A., Ponomareva L.A., Ivanova N.V., Polonikov A.V., Ivanova O.Yu., Bushueva O.Yu. Analysis of association of single nucleotide polymorphisms of genes for aryl hydrocarbon receptor signaling pathway with predisposition to uterine fibroids. Medical Genetics. 2020;19(6):55-57. (In Russ.)

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ISSN 2073-7998 (Print)