Role of polymorphic variants of angiotensin-converting gene (ACE) in heart failure development

Chronic heart failure (CHF) is one of the high-end causes of populations disability and mortality. Considering the fundamental role of neurohormonal systems in CHF development, the current approach is the study of genes, what expression products take part in formation of different types for myocardial remodeling and CHF progression. Three polymorphic loci in ACE gene- rs4343 (2350 G>А) , rs4291 (240A>T), rs4340 (I/D) in 271 patient of CHF (functional class II-IV) with different types of the left ventricle (LV) remodeling and 194 conditionally healthy men and women of corresponding age, also their haplotypes were studied. Homozygous genotypes *G*G locus rs4343 and *D*D locus rs4340 , also haplotype, based on these two loci, *DG gene ACE , are significant for CHF developing and remodeling LV, considering different types. By revising haplotypes for all three polymorphic loci of ACE gene (rs4291 , rs4340 and rs4343 ), the predominance of haplotype *TDG was statistically significant for patients with marked hypertrophy LV and moderate hypertrophy LV.

ремоделирование левого желудочка, ХСН, ген ангиотензин-превращающего фермента (АСЕ), полиморфный локус, генотип, гаплотип, remodeling of the left ventricle, chronic heart failure (CHF), angiotensin-converting enzyme gene (ACE), polymorphic locus, genotype, haplotype

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