Analysis of abnormalities of chorion karyotype in cases of non-developing pregnancy (Yaroslavl Regional Perinatal Center)
https://doi.org/10.1234/XXXX-XXXX-2016-5-45-47
Abstract
The research of the reasons of non-developing pregnancy is actual as it represents a serious problem in practice of obstetrics and gynecology.The aim of the research was the comparative study of frequency and spectrum of chromosomal pathologies in patients with non-developing natural pregnancy. We present the results of cytogenetic analysis of spontaneously aborted tissues from 120 patients. Abnormal karyotype in сhоrion was revealed in 74% of cases. The major types of chromosomal abnormalities are trisomies in 54% of cases and triploidies in 12%. We also analyzed the frequency and spectrum of chromosomal pathologies with due regard for patients’ age, fact of non-devloping natural pregnancy in patients’ overall history and fetal age. The rate of abnormal karyotypes in our research is higher in comparison with similar Russian and foreign studies.
About the Authors
S. V. Tikhomirova
Yaroslavl State Medical University; Regional Perinatal Center
Russian Federation
Russian Federation
A. G. Diunov
Yaroslavl State Medical University
Russian Federation
Russian Federation
D. L. Guriev
Yaroslavl State Medical University; Regional Perinatal Center
Russian Federation
Russian Federation
S. Yu. Nestuley
Regional Perinatal Center
Russian Federation
Russian Federation
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Review
For citations:
Tikhomirova S.V., Diunov A.G., Guriev D.L., Nestuley S.Yu. Analysis of abnormalities of chorion karyotype in cases of non-developing pregnancy (Yaroslavl Regional Perinatal Center). Medical Genetics. 2016;15(5):45-47. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-5-45-47
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