The role of CORO2A gene regulatory sites in development predisposition to preeclampsia
https://doi.org/10.1234/XXXX-XXXX-2016-5-32-34
Abstract
Regulatory single nucleotide polymorphisms (rSNPs) play a significant role in the development of human pathology by altering the level of candidate genes expression. The purpose of this research was to study preeclampsia (PE) genetics components via the regulatory polymorphic variants of the new CORO2A candidate gene. In this work we analyzed five rSNPs. Three ethnic group have been studied (Yakut, Russian, Buryat). We have detected significant associations of PE with 2 rSNPs in CORO2A gene: rs10985257 and rs735111.The results of this study provide evidence of a significant role of the new CORO2A candidate gene in development of variability of placental tissue expression level in PE and in normal pregnancy.
About the Authors
V. N. Serebrova
Research Institute of Medical Genetics
Russian Federation
Russian Federation
E. A. Trifonova
Research Institute of Medical Genetics; National Research Tomsk State University
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics; National Research Tomsk State University
Russian Federation
Russian Federation
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Review
For citations:
Serebrova V.N., Trifonova E.A., Stepanov V.A. The role of CORO2A gene regulatory sites in development predisposition to preeclampsia. Medical Genetics. 2016;15(5):32-34. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-5-32-34
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