The association of the MYH7 gene R249Q mutation with sudden cardiac death
https://doi.org/10.1234/XXXX-XXXX-2016-4-43-45
Abstract
The aim of the study is investigation of the association between the MYH7 gene R249Q (rs3218713) mutation and sudden cardiac death (SCD). Materials and methods. The SCD group was formed using WHO criteria for sudden cardiac death (n = 379, mean age 53,2 ± 8,7 years, men - 70.9%, women - 29.1%), the control group was selected according to sex and age from the DNA bank of HAPIEE, MONICA (n = 377, mean age 53,1 ± 8,3 years, men - 68.3%, 31.7% of women). DNA was isolated by phenol-chloroform extraction of the myocardial tissue of persons who died of sudden cardiac death, and venous blood of the persons included in the control group. Genotyping was done by PCR followed by analysis of restriction fragment length polymorphism. Results. In the SCD and control groups were not found carriers of the rare allele A of the MYH7 gene R249Q mutation. Conclusions. The MYH7 gene R249Q mutation is not associated with the SCD in the sample suddenly deceased residents of Novosibirsk.
Keywords
внезапная сердечная смерть,
rs3218713,
R249Q,
MYH7,
Arg249Gln,
sudden cardiac death,
rs3218713,
R249Q,
MYH7,
Arg249Gln
About the Authors
A. A. Ivanova
Institution of Internal and Preventive Medicine
Russian Federation
Russian Federation
V. N. Maksimov
Institution of Internal and Preventive Medicine; Novosibirsk State Medical University
Russian Federation
Russian Federation
S. V. Savchenko
Novosibirsk State Medical University; Novosibirsk Regional Office of Forensic Medical Examination
Russian Federation
Russian Federation
M. I. Voevoda
Institution of Internal and Preventive Medicine; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Ivanova A.A., Maksimov V.N., Savchenko S.V., Voevoda M.I. The association of the MYH7 gene R249Q mutation with sudden cardiac death. Medical Genetics. 2016;15(4):43-45. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-4-43-45
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