Analysis of polymorphisms of genes regulating the immune response in patients with atopic asthma
https://doi.org/10.1234/XXXX-XXXX-2016-4-36-38
Abstract
Topicality. The search for the associations of functionally polymorphisms of gene cytokines as potential markers of the disease, which influence both immune response and inflammatory process, is an actual aim of studying immune genetic factors of atopic bronchial asthma (ABA). Aim. To study the associations of polymorphisms of IL5 (rs2069812), IL12B (rs3212227), TGFB1 (rs1800469), IFNG (rs2069705) with ABA in depends from the stage of the disease control. Methods. For genotyping we have used PCR-PLRF-analysis. Results. No statistically significant difference was found in the distribution of the IL5, IL12B, TGFB1, IFNG polymorphisms between ABA patients and controls in this case-control study. The distribution of the frequencies of gene variants corresponded to the Europeans. Conclusions. As a result of our research we didn’t find any associations between polymorphisms of IL5, IL12B, TGFB1, IFNG genes and ABA including the level of the disease control.
Keywords
атопическая бронхиальная астма,
полиморфизм,
IL5,
IL12B,
TGFB1,
IFNG,
atopic asthma,
polymorphism,
IL5,
IL12B,
TGFB1,
IFNG
About the Authors
V. B. Epaneshnikova
Scientific Research Institute of medical problems of the North
Russian Federation
Russian Federation
M. V. Smolnikova
Scientific Research Institute of medical problems of the North
Russian Federation
Russian Federation
S. V. Smirnova
Scientific Research Institute of medical problems of the North
Russian Federation
Russian Federation
References
1. March ME, Sleiman PM, Hakonarson H. The genetics of asthma and allergic disorders. Discov. Med. 2011;11(56):35-45.
2. Коненков ВИ, Авдошина ВВ, Ракова ИА и др. Комплексная оценка уровня ConA-индуцированной продукции цитокинов в культуре мононуклеарных клеток периферической крови здоровых лиц. Медицинская иммунология. 2006;8(4):517-522.
3. Фрейдин МБ, Пузырев ВП, Огородова ЛМ. Полиморфизм генов интерлейкинов и их рецепторов: популяционная распространенность и связь с атопической бронхиальной астмой. Генетика. 2002;38(12):1-9.
4. Бабушкина НП, Брагина ЕЮ, Буйкин СВ и др. Ассоциации полиморфных вариантов генов подверженности бронхиальной астме. Медицинская генетика. 2015;14(5):28-36.
5. Pulleyn LJ, Newton R, Adcock IM, Barnes PJ. TGFbeta1 allele association with asthma severity. Hum Genet. 2001 Dec;109(6):623-627.
6. Wang D, Zhong X, Huang D et al. Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis. PLoS One. 2014 Jan 24;9(1):e87049.
Review
For citations:
Epaneshnikova V.B., Smolnikova M.V., Smirnova S.V. Analysis of polymorphisms of genes regulating the immune response in patients with atopic asthma. Medical Genetics. 2016;15(4):36-38. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-4-36-38
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