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Cognitive domains association with genetic variability of apolipoprotein E in a sample of elderly Russians
https://doi.org/10.25557/2073-7998.2020.04.27-29
Abstract
The search for genetic variants linking the decline in various areas of cognitive processes with age and Alzheimer’s disease is relevant. The aim was to search for the relationship of protein haplotypes of two polymorphic variants in the APOE gene with the eight cognitive function domains variability in f the elderly. Domains were determined by the battery score of the Montreal Cognitive Assessmnet (MoCA). The two most highly statistically significant associations were identified for the ε3/ε3 genotype in comparison with carriers of the ε4 allele. These are memory (p = 0.002) and visuospatial abilities (p = 0.007) domains. No statistically significant associations were revealed for cognitive domains: attention and concentration, executive functions, language, abstraction, calculations and orientation. Possibly, the identified associations determine the general genetic baseline of inheritance of Alzheimer’s disease, mental disorders, dementia and intelligence in the elderly.
About the Authors
A. V. Marusin
The Research Institute for Medical Genetics, National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
O. A. Makeeva
The Research Institute for Medical Genetics, National Research Medical Center, Russian Academy of Sciences; Center for Clinical Research «Nebbiolo»
Russian Federation
Russian Federation
K. V. Vagaitseva
The Research Institute for Medical Genetics, National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Bocharova
The Research Institute for Medical Genetics, National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Stepanov
The Research Institute for Medical Genetics, National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
Review
For citations:
Marusin A.V., Makeeva O.A., Vagaitseva K.V., Bocharova A.V., Stepanov V.A. Cognitive domains association with genetic variability of apolipoprotein E in a sample of elderly Russians. Medical Genetics. 2020;19(4):27-29. (In Russ.) https://doi.org/10.25557/2073-7998.2020.04.27-29
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