Genetic portrait of intrinsic drug resistance of various morphological structures in breast cancer
https://doi.org/10.1234/XXXX-XXXX-2016-4-21-24
Abstract
We aimed to estimate the influence of intratumor morphological heterogeneity of breast cancer on the chemotherapy response depending on clinical-pathological parameters and to identify the molecular mechanisms of the association, obtained here, by whole transcriptome profiling and PCR analysis. We found the significant association between the presence of alveolar and trabecular structures in breast tumors and chemoresistance and identified expression markers: NAT1 , ABCA12 , ABCC1 , ABCG1 , PIK3C3 , TXN2 , SLC23A2 , SLC25A13 , SLC1A3 , and UBE2S that may determine the differential contribution of morphological structures in breast cancer chemoresistance.
About the Authors
T. S. Gerashchenko
National Research Tomsk State University
Russian Federation
Russian Federation
E. V. Denisov
National Research Tomsk State University
Russian Federation
Russian Federation
M. V. Zavyalova
National Research Tomsk State University; Siberian State Medical University
Russian Federation
Russian Federation
N. V. Litviakov
National Research Tomsk State University
Russian Federation
Russian Federation
S. V. Vtorushin
Tomsk Cancer Research Institute; Siberian State Medical University
Russian Federation
Russian Federation
D. N. Pautova
National Research Tomsk State University
Russian Federation
Russian Federation
N. V. Krakhmal
Siberian State Medical University
Russian Federation
Russian Federation
N. A. Skryabin
National Research Tomsk State University; Research Institute of Medical Genetics
Russian Federation
Russian Federation
A. A. Sleptcov
National Research Tomsk State University; Research Institute of Medical Genetics
Russian Federation
Russian Federation
N. V. Cherdyntseva
National Research Tomsk State University
Russian Federation
Russian Federation
V. M. Perelmuter
Tomsk Cancer Research Institute; Siberian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Gerashchenko T.S., Denisov E.V., Zavyalova M.V., Litviakov N.V., Vtorushin S.V., Pautova D.N., Krakhmal N.V., Skryabin N.A., Sleptcov A.A., Cherdyntseva N.V., Perelmuter V.M. Genetic portrait of intrinsic drug resistance of various morphological structures in breast cancer. Medical Genetics. 2016;15(4):21-24. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-4-21-24
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