ROLE OF MICRORNAS IN ETIOLOGY, PATHOGENESIS, DIAGNOSIS AND TREATMENT OF STROKE
https://doi.org/10.1234/XXXX-XXXX-2015-1-3-12
Abstract
Stroke, that is one of the leading causes of death and disability in the world, is a multifactorial disease. It develops due to interaction of environmental factors and genetic predisposition, which structure and mechanisms are intensively studied. The most common type of stroke is the ischemic stroke. One of the new approaches in the study of stroke pathogenesis is researching microRNAs expression profiles. MicroRNAs are short noncoding RNAs that play an important role in the regulation of gene expression at the transcriptional and post-transcriptional levels. This review shows the significant role of microRNAs in stroke's etiology, pathogenesis, diagnostics and treatment. In stroke etiology, microRNAs, changing their expression profile, modulate the pathogenic mechanisms of atherosclerosis, hyperlipidemia, arterial hypertension, diabetes and plaque rupture. MicroRNAs can modify clinical aspects and clinical outcome by the influence on basic pathogenic mechanisms of ischemic brain damage (apoptosis, inflammation, brain edema). MicroRNAs may serve as biomarkers of stroke allowing to determine the type of stroke or the severity of brain damage, and they also could be used in the stroke treatment.
About the Authors
I. S. Zhanin
Federal State Budgetary Institution «Scientific Centre of Children's Health» under the Russian Academy of Medical Sciences; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A.. Y Asanov
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. G. Pinelis
Federal State Budgetary Institution «Scientific Centre of Children's Health» under the Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Zhanin I.S., Asanov A.Y., Pinelis V.G. ROLE OF MICRORNAS IN ETIOLOGY, PATHOGENESIS, DIAGNOSIS AND TREATMENT OF STROKE. Medical Genetics. 2015;14(1):3-12. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-1-3-12
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