Role of polymorphisms of genes involved in glucocorticoid metabolism in the risk of bronchial asthma

Bronchial asthma is one of the most common severe and disabling multifactorial diseases. The association analysis of polymorphisms of glucocorticoid receptor gene NR3C1 ( rs41423247 ), corticotropin-releasing hormone receptor 1 gene CRHR1 ( rs242939, rs1876828, rs242941 ), T-box transcription factor gene TBX21 ( rs2240017 ) in asthmatic patients treated with corticosteroids and unrelated healthy from Bashkortostan Republic was performed. The association of NR3C1 polymorphism rs41423247 with decline in lung functions in patients has been revealed. The genotype rs242941*C/A and haplotype AA ( rs242939, rs242941 ) of gene CRHR1 were significantly associated with BA in Bashkirs, while the genotype rs41423247*С/G of gene NR3C1 was associated with BA in Tatars.

бронхиальная астма, полиморфный вариант, гены, ответственные за метаболизм глюкокортикостероидов, ассоциация, bronchial asthma, polymorphism, genes involved in glucocorticoid metabolism, association

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