Polymorphism G276Т of the adiponectin gene is associated with type 2 diabetes mellitus in Kyrgyz Population

Aim: To study an association of the G276Т polymorphism of the adiponectin ( ADIPOQ ) gene with type 2 diabetes mellitus (T2DM) in Kyrgyz Population. Materials and Methods: We examined 107 patients (female - 47, male - 60) with T2DM and 181 apparently health controls (female - 96, male - 85). The genotypes for adiponectin polymorphism G276T were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of the variant T allele and genotype GT and TT of 276 ADIPOQ gene was significantly higher among T2DM patients compared with control subjects (c² = 4,98; р = 0,026 for allele; c² = 6,31, р = 0,043 for genotype). Subjects having the T-allele of SNP276 had 1,57-fold [OR = 1,57 (1,07-2,30); p = 0,026] higher risk of developing T2DM compared with subjects carrying neither of these alleles. Individuals carrying the G/Т genotype of 276 ADIPOQ gene had 1,62 fold [OR = 1,62 (1,01-2,62); p = 0,043] higher risk of T2DM than subjects homozygous for the common GG-genotype. The G allele as well as homozygous genotype G/G of the polymorphic locus gene are significantly protective against the development of type 2 diabetes [OR = 0,64 (0,43-0,93); p = 0,026 and OR = 0,55 (0,34-0,90); p = 0,043, respectively]. Conclusion: In kyrgyz population the T allele and G/T genotype of polymorphism loci G276T of ADIPOQ gene is associated with T2DM.

сахарный диабет 2 типа, ген адипонектина, полиморфизм, ассоциация, кыргызская популяция, type 2 diabetes mellitus, adiponectin gene, polymorphism, association, kyrgyz population

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