Prognostic value of embryonic kariotypes and previous pregnancy outcomes in recurrent pregnancy loss
https://doi.org/ 10.25557/2073-7998.2018.11.15-19
Abstract
Recurrent pregnancy loss (RPL) is a multifactorial pathology with significant proportion of idiopathic cases. Comparative analysis of the chromosomal abnormalities rates in abortions in primary vs. secondary RPL can shed light on the genetic heterogeneity of these groups. The aim of this study was to establish the contribution of the embryonic chromosomal abnormalities in the pathogenesis of primary and secondary RPL. Of the 563 abortuses karyotyped, 335 were from women with primary and 228 with secondary RPL. The frequency of chromosomal aberrations was 43.9% and 52.6% in the groups with primary and secondary RPL, respectively (p = 0.041). Double trisomy were revealed in 5.2% of abortuses and the most of cases were found in secondary RPL group (p = 0.0002). There were no significant differences in the frequency of involvement of individual chromosomes in aneuploidy between groups with primary and secondary RPL. The frequency of aneuploid pregnancy significantly higher in secondary RPL, and this difference is due to the «lack» of abortuses with abnormal karyotypes in older women with primary RPL.
About the Authors
T. V. Nikitina
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
E. N. Tolmacheva
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
N. N. Sukhanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
D. I. Zhigalina
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
L. I. Minaycheva
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
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Review
For citations:
Nikitina T.V., Sazhenova E.A., Tolmacheva E.N., Sukhanova N.N., Zhigalina D.I., Minaycheva L.I., Lebedev I.N. Prognostic value of embryonic kariotypes and previous pregnancy outcomes in recurrent pregnancy loss. Medical Genetics. 2018;17(11):15-19. (In Russ.) https://doi.org/ 10.25557/2073-7998.2018.11.15-19
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