Molecular mechanisms of disturbance of imprinted genes in pathology of pre-and postnatal development
https://doi.org/ 10.25557/2073-7998.2018.11.3-6
Abstract
Multiple epimutations in imprinted genes change the expression level of maternal and paternal genes. This leads to disturbance in embryonic and postembryonic human development. The phenomenon of multiple epimutations indicates the possibility of the existence of special mechanisms controlling the epigenetic status of multiple imprinted genome loci. Therefore, the study of these mechanisms is of interest. The following review is devoted to the new class of genes ( NLRP 2, NLRP 5, NLRP7 , KHDC3L , ZFP57 and PADI6 ), mutations in which are accompanied by multiple epimutations in imprinted loci both during embryonic development and hereditary syndromes.
About the Authors
E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of Russian Academy of Sciences
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Sazhenova E.A., Lebedev I.N. Molecular mechanisms of disturbance of imprinted genes in pathology of pre-and postnatal development. Medical Genetics. 2018;17(11):3-6. (In Russ.) https://doi.org/ 10.25557/2073-7998.2018.11.3-6
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