Association of mitochondrial genome polymorphism with quantitative traits of patients with myocardial infarction and diabetes
https://doi.org/10.1234/XXXX-XXXX-2015-10-21-24
Abstract
We studied the mitochondrial genome polymorphism in the group of patients with myocardial infarction, taking into account cooccurrence of the diabetes mellitus. Associations were investigated for the mtDNA polymorphism and body mass index, serum lipids, glucose levels and blood pressure. Association of haplogroup H with body mass index in the sample with infarction (p = 0,017) and with glucose levels in diabetic patients at admission (p = 0,03) has been found.
About the Authors
R. R. Salakhov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
O. A. Makeeva
Research Institute for Medical Genetics
Russian Federation
Russian Federation
V. V. Kashtalap
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
M. V. Golubenko
National Research Tomsk State University
Russian Federation
Russian Federation
References
1. Жейкова Т.В. Генетическая основа регуляции окислительного стресса: связь с продолжительностью жизни и ишемической болезнью сердца: Автореф. дисc. на соискание ученой степени к.м.н. - Томск, 2013. - 23 с.
2. Каретникова В.Н., Беленькова Ю.А., Зыков М.В., Кашталап В.В. и др. Уровень гликемии как фактор прогноза у больных инфарктом миокарда с подъемом сегмента ST // Кардиология. - 2012. - Т. 52, №1. - С. 26-31.
3. Морозова И.Ю., Наумова О.Ю., Рычков С.Ю., Жукова О.В. Полиморфизм митохондриальной ДНК в русском населении пяти областей Европейской части России // Генетика. - 2005. - Т. 41, №9. - С. 1265-1271.
4. Пузырев В.П. Генетический взгляд на феномен сочетанной патологии у человека // Медицинская генетика. - 2008. - №9. - С. 3-9
5. Пузырев В.П., Голубенко М.В., Фрейдин М.Б. Сфера компетенции митохондриальной генетики // Вестник РАМН. - 2001. - №10. - C. 31-37.
6. Пузырев В.П., Макеева О.А., Голубенко М.В. Гены синтропий и сердечно-сосудистый континуум // Вестник ВОГиС. - 2006. - Т. 10, №3. - С. 479-490.
7. Dzau V., Braunwald E. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement // Am. Heart. J. - 1991. - Vol. 121. - P. 1244-1263.
8. Gutierrez J., Ballinger S.W., Darley-Usmar V.M., Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells // Circ. Res. - 2006. - Vol. 99. - P. 924-932.
9. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT // Nucl. Acids. Symp. Ser. - 1999. - Vol. 41. - P. 95-98.
10. Kenney M.C., Chwa M., Atilano S.R., Falatoonzadeh P. et al. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases // Biochimica et Biophysica Acta. - 2014. - Vol. 1842, №2. - P. 208-219.
11. Kenney M.C., Chwa M., Atilano S.R., Pavlis J.M. et al. Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 Genes: implications for age-related macular degeneration // PLoS ONE. - 2013. - Vol. 8, №1. - e54339.
12. Martinez-Redondo D., Marcuello A., Casajus J.A., Ara I. et al. Human mitochondrial haplogroup H: he highest VO2max consumer - Is it a paradox? // Mitochondrion. - 2010. - Vol. 10. - P. 102-107.
13. Mountain J., Hebert J.M., Bhattacharyya S. et al. Demographic history of India and mtDNA-sequence diversity //Am. J. Hum. Genet. - 1995. - Vol. 56. - P. 979-992.
14. Mueller E.E., Eder W., Ebner S. et al. The Mitochondrial T16189C Polymorphism Is Associated with Coronary Artery disease in Middle European Populations // PLoS ONE. - 2011. - Vol. 6, №1. - e16455.
15. Palacin M., Alvarez V., Martin M., Diaz M. Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H // Mitochondrion. - 2011. - Vol. 11, №1. - P. 176-181.
16. Park K.S., Chan J.C., Chuang L.M. et al. A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians // Diabetologia. - 2008. - Vol. 51. - P. 602-608.
17. Poulton J., Luan J., Macaulay V. et al. Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study // NJ. Hum Mol Genet. - 2002. - Vol. 11, №13. - P. 1581-1583.
18. Salminen A., Ojala J., Kaarniranta K., Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases // Cell. Mol. Life Sci. - 2012. - Vol. 69. - P. 2999-3013.
19. Torroni A., Huoponen K., Francalacci P. et al. Classification of European mtDNAs from an analysis of three European populations // Genetics. - 1996. - Vol. 144. - P. 1835-1850.
Review
For citations:
Salakhov R.R., Makeeva O.A., Kashtalap V.V., Barbarash O.L., Golubenko M.V. Association of mitochondrial genome polymorphism with quantitative traits of patients with myocardial infarction and diabetes. Medical Genetics. 2015;14(10):21-24. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-10-21-24
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