Study of the role of cytokine genes’ polymorphisms 511C> T IL1, 174G> C IL6, 1082G> A IL10 in the development of chronic pancreatitis in residents of Central Russia
https://doi.org/10.25557/2073-7998.2018.06.35-38
Abstract
The aim of the study was to assesses the relationship between the polymorphisms (rs16944) of the interleukin-1, (rs1800795) of the interleukin-6 and (rs1800896) of the interleukin-10 genes with the development of chronic pancreatitis (CP) in the Russian population. Peripheral venous blood samples were obtained from 233 patients with CP and 132 healthy individuals. Genotyping of polymorphisms of the studied genes was carried out using the PCR method with discrimination of alleles with the TaqMan probes. Was found: the genotype 511CT IL1 (OR = 1,58 95%CI 1,01-2,48, p = 0,04) and the genotype 1082GA IL10 (OR = 1,58 95%CI 1,03-2,42, p = 0,04) were associated with an increased risk of developing chronic pancreatitis. Combinations of genotypes IL1 and IL6 - 511ТТх174GC (OR = 0,46, 95%CI 0,22-0,98, p = 0,04), IL1 and IL10 - 511CCх1082AA (OR = 0,19 95%CI 0,07-0,50, p = 0,0002) and 511ТТх1082GG (OR = 0,41 95%CI 0,17-0,96, p = 0,04); IL6 and IL10 - 174GGх1082GG (OR = 0,42, 95%CI 0,19-0,93, p = 0,03), on the contrary, were associated with low risk of the disease.
About the Authors
T. A. Samgina
Kursk State Medical University
Russian Federation
Russian Federation
P. M. Nazarenko
Kursk State Medical University
Russian Federation
Russian Federation
V. A. Lazarenko
Kursk State Medical University
Russian Federation
Russian Federation
G. A. Zhivotova
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Samgina T.A., Nazarenko P.M., Lazarenko V.A., Zhivotova G.A., Polonikov A.V. Study of the role of cytokine genes’ polymorphisms 511C> T IL1, 174G> C IL6, 1082G> A IL10 in the development of chronic pancreatitis in residents of Central Russia. Medical Genetics. 2018;17(6):35-38. (In Russ.) https://doi.org/10.25557/2073-7998.2018.06.35-38
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