VARIABILITY OF INTERLEUKIN 4 AND ITS RECEPTOR GENES IN NATIVE POPULATIONS OF SIBERIA
https://doi.org/10.1234/XXXX-XXXX-2013-4-38-40
Abstract
Genetic diversity of SNP markers of Interleukin 4 alpha and Interleukin 4 receptor genes was investigated in 4 populations of native Siberian ethnic groups (Buryat, Yakut, Ket and Khant). In the populations under study, except Khants, the close spectrum of allele frequencies and similar level of expected heterozygosity were revealed and low level of genetic differentiation was found.
About the Authors
V. A. StepanovRussian Federation
E. A. Trifonova
Russian Federation
K. V. Simonova
Russian Federation
A. A. Cherednichenko
Russian Federation
References
1. Степанов В.А., Канделария П., Кхо С. и др. Деканализация иммунного ответа при расселении современного человека: связь генетического разнообразия в генах иммунной системы с климато-географическими факторами // Медицинская Генетика. — В печати.
2. Abi-Rached et al. The shaping of modern human immune systems by multiregional admixture with archaic humans // Science. — 2011. — Vol. 334, №6052. — P. 89—94.
3. Basehore M.J. Howard T.D., Lange L.A. et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects // J. Aliergy Clin. Immunol. — 2004. — Vol. 114. — P. 80—87.
4. Battle N.C., Choudhry S., et al. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma // Am. J. Respir. Crit. Care. Med. — 2007. — 1. — Vol. 175, №9. — P. 881—887.
5. Beghe B. et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population // Clin. Exp. Allergy. — 2003. — Vol. 33. — P. 1111—1119.
6. Granada M., Wilk J.B., Tuzova M. et al. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study // J. Allergy Clin. Immunol. — 2012. — Vol. 129. — P. 840—845.
7. Hancock A.M., Witonsky D.B., Alkorta-Aranburu G. et al. Adaptations to climat-mediated selectivre pressures in humans // PLoS Genetics. — 2011. — Vol. 7, №4. — e1001375. doi: 10.1371 /journal.pgen. 1001375
8. Isidoro-Garcia M., Davila I., Laffond E. et al. Interleukin-4 (IL4) and interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study // Clin. And Mol. Aliergy. — 2005. — Vol. 3.
9. Izuhara K., Shirakawa T. Signal transduction via the interleukin-4 receptor and its corteiation with atopy // Int. J. Mol. Med. 1999. — Vol. 3, №1. — P. 3—10.
10. Kabesch M., Tzotcheva I., Carr D. et al. A compiete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood // J. Aliergy Clin. Immunol. — 2003. — Vol. 112. — P. 893—898.
11. Li Y., Guo B., Zhang L. et al. Association between C-589T polymorphisms of interleukin-4 gene promoter and asthma: a meta-analysis // Respir. Med. — 2008. — Vol. 102. — P. 984—982.
12. Migliaccio C., Patuzzo C. et al. No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families // Eur. J. Immunogenet. — 2003. — Vol. 30, №5. — P. 349—353.
13. Nieters A., Linseisen J., Becker N. Association of polymorphisms in Th1., Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg // Clin. Exp. Allergy. — 2004. — Vol. 34, №3. — P. 346—353.
14. Sabeti P.C., Schaffner S.F., Fry B. еt al. Positive natural seiection in the human lineage // Science. — 2006. — Vol. 312. — P. 1614—1620.
15. Suzuki I., Hizawa N., Yamaguchi E., Kawakami Y. Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels // Clin. Exp. Allergy. — 2000. — Vol. 30. — P. 1746—1749.
16. Yang H.J. Association between the interleukin-4 gene C-589T and C+33T polymorphisms and asthma risk: a meta-analysis // Arch. Med. — res. 2—13. — Vol. 44. — P. 127—135.
Review
For citations:
Stepanov V.A., Trifonova E.A., Simonova K.V., Cherednichenko A.A. VARIABILITY OF INTERLEUKIN 4 AND ITS RECEPTOR GENES IN NATIVE POPULATIONS OF SIBERIA. Medical Genetics. 2013;12(4):38-40. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2013-4-38-40