Studying the role of genetic component in development of different clinical forms of TB
https://doi.org/10.25557/2073-7998.2018.02.29-34
Abstract
Tuberculosis (TB) is a global health problem, both in the world and in our country, especially in the Siberia and the Far East. Well known that there are genetic factors that influence to TB predisposition. The aim of this work was studying the role of IL-12 / IFN-g gene polymorphisms in the development of different clinical forms of TB. The study was conducted in a population of russians in Tomsk: TB patients (n = 331) and healthy donors (n = 279). Patients were divided into subgroups: patients with primary (n = 61) and secondary (n = 270) TB. As well as patients with infiltrative (n = 155) and disseminated (n = 68) TB. The effect of allele A and genotype AA of the STAT1 gene on the development of secondary TB (p = 0.0097) was shown. Also, the association of the C allele of the IL12RB1 gene and the CC genotype with the development of infiltrative TB has been identified. Our results suggest differences in genetic predisposition to various forms of TB.
About the Authors
A. F. Garaeva
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
A. A. Rudlo
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
O. V. Kolokolova
Siberian State Medical University
Russian Federation
Russian Federation
O. N. Lipaenkova
Tuberculosis hospital
Russian Federation
Russian Federation
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk NRMC; Siberian State Medical University
Russian Federation
Russian Federation
M. B. Freidin
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
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Review
For citations:
Garaeva A.F., Rudlo A.A., Bragina E.Yu., Babushkina N.P., Kolokolova O.V., Lipaenkova O.N., Puzyrev V.P., Freidin M.B. Studying the role of genetic component in development of different clinical forms of TB. Medical Genetics. 2018;17(2):29-34. (In Russ.) https://doi.org/10.25557/2073-7998.2018.02.29-34
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