Relationship between the genetic structure of human populations and geographical and climatic parameters
https://doi.org/10.25557/2073-7998.2018.01.37-40
Abstract
Human populations live in different environmental conditions that require adaptation, especially to extreme environmental factors. The action of adaptive evolution is also reflected on human populations’ genetic constitution. The study highlights the variability analysis of 25 SNPs single nucleotide polymorphisms (SNP) related to adaptation to a cold climate, as well as influence of climatic and geographical factors on the genetic diversity of human populations. The growth of the genetic diversity among the studied markers from Africa according to a modern human’s displacement around the earth identified. Probably, the variability of alleles associated with adaptation to climate in some populations could be explained in the framework of the hypothesis of canalization/decanalization of genome-phenome relationships under natural selection during modern human dispersion.
About the Authors
A. A. Popovich
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
K. V. Vagaitseva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
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Review
For citations:
Popovich A.A., Vagaitseva K.V., Bocharova A.V., Stepanov V.A. Relationship between the genetic structure of human populations and geographical and climatic parameters. Medical Genetics. 2018;17(1):37-40. (In Russ.) https://doi.org/10.25557/2073-7998.2018.01.37-40
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