Mitochondrial DNA polymorphism and cardiovascular continuum diseases
https://doi.org/10.25557/2073-7998.2018.01.9-13
Abstract
Mitochondrial genome, encoding respiratory chain subunits, is characterized by high polymorphism level in human populations. In most studies for susceptibility genes for common diseases, including cardiovascular diseases, the analysis is limited to the nuclear genome. It was shown that particular mtDNA genotypes may differ by oxidative phosphorylation efficiency. Some associations of mtDNA polymorphisms with cardiovascular diseases have been found. According to our results and published data, we suggest that mtDNA effect on cardiovascular system does not manifest in predisposition to cardiovascular diseases themselves but rather in risk of complications and comorbidities in the cardiovascular continuum.
About the Authors
M. V. Golubenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Research Institute for Complex Issues of Cardiovascular diseases
Russian Federation
Russian Federation
R. R. Salakhov
Research Institute for Complex Issues of Cardiovascular diseases
Russian Federation
Russian Federation
T. V. Shumakova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. V. Buikin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. A. Makeeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Golubenko M.V., Salakhov R.R., Shumakova T.V., Buikin S.V., Makeeva O.A., Nazarenko M.S., Puzyrev V.P. Mitochondrial DNA polymorphism and cardiovascular continuum diseases. Medical Genetics. 2018;17(1):9-13. (In Russ.) https://doi.org/10.25557/2073-7998.2018.01.9-13
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