NIPT high-risk of trisomy 16 as a predictor of complicated pregnancy course

Fetal trisomy 16 is one of the frequent causes in first-trimester spontaneous pregnancy losses. Also, it is often found confined to the placenta (confined placental mosaicism), which, according to the literature, may be the cause of complicated pregnancy course. Currently, a noninvasive prenatal testing (NIPT) is widely used to detect risks of fetal chromosomal abnormalities (CA) based on the analysis of cell-free fetoplacental DNA. Whole-genome NIPT allows to determine the risks of rare CAs, including trisomy 16. Here we presented 5 NIPT high-risk cases of trisomy 16 with a complicated course of pregnancy.

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