Dynamics of gene pool of megapolis population by 18 STR of Y-chromosome and 27 autosomal STR under action of migration

In megalopolis, the main factor of dynamics of the gene pool is migration. In two generations of Moscow residents and, also, in the samples from Saint-Petersburg and Novosibirsk, 18 STR of Y-chromosome were studied, by obtained haplotypes Y-chromosome haplogroups were predicted using Internet-predictor Whit Athey’s. In two generations of Muscovites, 27 autosomal STR, not included in the system CODIS, were studied. In comparison of the sample from Novosibirsk with the samples from Saint-Petersburg and the young sample from Moscow, statistically significant estimates of genetic differentiation (FST) by profiles of 18 STR Y-chromosome were observed. For two samples of Muscovites, FST value by 18 STR of Y-chromosome was substantially higher, than the value of FST obtained by autosomal STR. The results of the investigation by DNA-markers of Y-chromosome (18 STR, haplogroups) and 27 autosomal STR demonstrate validity of specific approach for developing reference data bases for megalopolises by different DNA-markers, mediated by individual dynamics in generations. Obtained results support necessity of developing separate data bases for each megalopolis for DNA-identification and their timely update depending on gene pool dynamics in generations under action of migration.

1. Kurbatova O.L., Yankovsky N.K. Migration as the main factor of the Russia’s urban population dynamics. Russ J Genet. 2016; 52(7): 726–745.

2. Kurbatova O.L., Gracheva A.S., Pobedonostseva E.Y., Udina I.G. et al. Genetic Demography of the Populatio of Moscow: Migration Processes. Russ J Genet.2021; 57(12): 1443–1453.

3. Kurbatova O.L., Udina I.G., Gracheva A.S. et al. Genetic Demography of the Population of St. Petersburg: Migration Processes. Russ J Genet. 2019; 55(9):1119–1129.

4. Kurbatova O.L., Udina I.G., Gracheva A.S., et al. Genetikodemograficheskiye parametry naseleniya g. Novosibirska [Geneticdemographic parameters of the Novosibirsk population]. Genetika [Genetics]. 2018;54(13):74-84. (In Russ.)

5. Gracheva A.S., Pobedonostseva E.Y., Udina I.G. et al. Territorial Subdivision of the Megalopolis Population by the Ethnic Trait in Relation to the Problem of Creating Genetic Databases: Moscow. Russ J Genet. 2020; 56(12):1520–1529.

6. Gracheva A.S., Pobedonostseva E.Y., Udina I.G. et al. Territorial Subdivision of the Megalopolis Population by the Ethnic Trait in Relation to the Problem of Creating Genetic Databases. St. Petersburg. Russ J Genet. 2019; 55(12):1536–1544.

7. Gracheva A.S., Pobedonostseva E.Yu., Udina I.G., Kurbatova O.L. Territorial subdivision of the megalopolis population by the ethnic traitin relation to the problem of creating genetic databases. Novosibirsk. Genetika [Genetics]. 2018;54(13): 85-90. (In Russ.)

8. Udina I.G., Gracheva A.S., Kurbatova O.L. Frequencies of Y-Chromosome Haplogroups and Migration Processes in Three Generations of Moscow Residents. Russ J Genet. 2022; 58(11): 1365–1372.

9. Udina I.G., Gracheva A.S., Borinskaya S.A., Kurbatova O.L. Distribution Peculiarities of Y-Chromosome Haplogroups in the Population of St. Petersburg in Connection with the Problem of Creation of Reference Databases. Russ J Genet. 2023; 59(11): 1216– 1221.

10. Athey T.W. Haplogroup prediction from Y-STR values using a Bayesian allele frequency approach. J. Genet. Geneal. 2006;2: 34–39.

11. Meza García L.A. Evolutionary Bioinformatics Online 2005:1 47-50 47 Arlequin (version 3.0): An integrated software package for population genetics data analysis. (URL: http://cmpg.unibe.ch/software/arlequin35)