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Transcriptome discordance in colon tumors and metastases: a search for metastasis markers
https://doi.org/10.25557/2073-7998.2026.04.38-42
Abstract
This brief report presents the results of a transcriptome profile analysis of colon tumors and liver metastases during FOLFOXIRI chemotherapy in patients with metastatic colon cancer (mCRC). Whole-transcriptome sequencing was performed on the DNBSeq platform using the DNBSEQ-G400RS High-throughput Sequencing Kit (MGI, China). Transcriptome transformation of primary colon tumors and liver metastases during preoperative FOLFOXIRI chemotherapy in combination with targeted therapy was demonstrated. A potential panel of candidate genes, such as IL1RN, DUSP1, NAMPT, IL7R, PCSK9, DGAT1, EPS8L2, and FOS that are involved in metastasis and response to FOLFOXIRI was identified.
Supporting agencies: This study was supported by Russian Science Foundation grant No. 22-15-00212.
About the Authors
N. N. Babyshkina
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
2 Moskovsky tract, Tomsk, 634050
T. A. Dronova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
D. N. Kostromitskiy
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
A. Yu. Dobrodeev
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
P. A. Gervas
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
N. V. Cherdyntseva
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
5 Kooperativny st., Tomsk, 634050
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For citations:
Babyshkina N.N., Dronova T.A., Kostromitskiy D.N., Dobrodeev A.Yu., Gervas P.A., Cherdyntseva N.V. Transcriptome discordance in colon tumors and metastases: a search for metastasis markers. Medical Genetics. 2026;25(4):38-42. (In Russ.) https://doi.org/10.25557/2073-7998.2026.04.38-42
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