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Polymorphism rs1136141 HSPA8 is associated with an increase in the brain infarct size
https://doi.org/10.25557/2073-7998.2025.11.139-140
Abstract
Ischemic stroke (IS) is one of the leading causes of disability and mortality. A key role in its pathogenesis is played by impaired proteostasis and, accordingly, impaired functions of heat shock proteins (HSP). In this study, we sought to evaluate the impact of polymorphisms of the HSPA8 gene encoding heat shock protein on the clinical course of IS. DNA samples of 888 patients with IS were genotyped by real-time PCR at three loci of the HSPA8 gene (rs1461496, rs10892958, rs1136141). The analysis showed that the rs1136141 HSPA8 polymorphism is associated with an increase in the brain infarct size (β = 112.5±54.07, Pperm = 0.04). Bioinformatic analysis of this polymorphism established that the A allele of rs1136141 HSPA8 may be associated with the regulation of the immune response, apoptosis and angiogenesis, which in turn may contribute to tissue damage during ischemia/reperfusion.
Supporting agencies: Kursk State Medical University
About the Author
I. V. Shilenok
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
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Review
For citations:
Shilenok I.V. Polymorphism rs1136141 HSPA8 is associated with an increase in the brain infarct size. Medical Genetics. 2025;24(11):139-140. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.139-140
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