Obesity modifies the effects of SERBP1 polymorphisms on hemocoagulation and coronary artery stenosis

Abstract

In the pathogenesis of coronary heart disease (CHD), which develops against the background of progression of atherosclerosis, the participation of molecular chaperones is one of the determining factors. SERBP1 (Hero45), an RNA-binding protein, has recently been classified as a new class of Hero proteins with chaperone-like activity, which makes its study particularly relevant. In the present study, 836 patients with CHD were genotyped for five single nucleotide polymorphisms of SERBP1 using PCR. In this study, we report that single nucleotide polymorphisms of the SERBP1 gene in non-obese patients (BMI < 30) are associated with an increase in international normalized ratio (INR) (rs4655707 SERBP1: β = 0.4191 ± 0.1661, P_perm = 0.007; rs6702742 SERBP1: β = 0.4195 ± 0.1719, P_perm = 0.0098) and a decrease in the percentage of left coronary artery (LCA) stenosis (rs12561767 SERBP1: β = -1.277 ± 0.4637, P_perm = 0.02; rs6702742 SERBP1: β = -1.277 ± 0.4637, P_perm = 0.02). Taken together, our study provides evidence that SERBP1 may modulate hemostasis parameters and stenosis in non-obese CAD patients.