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GWAS-significant loci for severe COVID-19 affect biochemical parameters in patients with coronary artery disease
https://doi.org/10.25557/2073-7998.2025.11.84-85
Abstract
Severe COVID-19, including hospitalization and mortality, is determined by both genetic risk factors and concomitant chronic diseases, among which coronary artery disease (CAD) plays a leading role. The aim of this study was to evaluate the impact of CAD on the associations between biochemical markers of patients with severe COVID-19 and GWAS-significant loci. Genotyping of 199 patients hospitalized with severe COVID-19 was carried out by PCR for 10 GWAS loci. In the presence of concomitant CAD in patients with severe COVID-19, polymorphic variants were associated with an increase in plasma fibrinogen: rs12610495 DPP9 (β = 1.528±0.5637, Pperm = 0.02), rs7949972 ELF5 (β = 1.345±0.5015, Pperm = 0.02), rs61882275 ELF5 (β = 1.345±0.5015, Pperm = 0.02); and with an increase in the steadystate spatial clot growth rate: rs11183780 CCHCR1 (β = 14.36±6.5, Pperm = 0.03). Thus, CAD modifies associations between biochemical markers and GWAS-significant loci in patients with severe COVID-19.
Supporting agencies: Kursk State Medical University
About the Author
A. V. Loktionov
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
References
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For citations:
Loktionov A.V. GWAS-significant loci for severe COVID-19 affect biochemical parameters in patients with coronary artery disease. Medical Genetics. 2025;24(11):84-85. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.84-85
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