medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2025.11.84-85medgen-3308Research ArticleКРАТКОЕ СООБЩЕНИЕBRIEF REPORTGWAS-значимые локусы тяжелого COVID-19 влияют на биохимические параметры у пациентов с ишемической болезнью сердцаGWAS-significant loci for severe COVID-19 affect biochemical parameters in patients with coronary artery diseaseЛоктионовА. В.LoktionovA. V.

305041, Курск, ул. К. Маркса, д.3

3, K. Marx st., Kursk, 305041

ofig27@rambler.ruФГБОУ ВО Курский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияKursk State Medical UniversityRussian Federation20252412202524118485Copyright © Локтионов А.В., 20252025Локтионов А.В.Loktionov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/3308

Тяжелое течение COVID-19, включая госпитализацию и смертность, обусловлено как генетическими факторами риска, так и сопутствующими хроническими заболеваниями, среди которых ишемическая болезнь сердца (ИБС) играет ведущую роль. Целью данного исследования было оценить влияние ИБС на ассоциации между биохимическими маркерами пациентов с тяжелым COVID-19 и GWAS-значимыми локусами. Генотипирование 199 пациентов, госпитализированных с тяжелым COVID19, осуществлялось методом ПЦР по 10 локусам GWAS. При наличии сопутствующей ИБС у пациентов с тяжелым COVID-19 полиморфные варианты были связаны с увеличением фибриногена в плазме: rs12610495 DPP9 (β = 1,528±0,5637, Pperm = 0,02), rs7949972 ELF5 (β = 1,345±0,5015, Pperm = 0,02), rs61882275 ELF5 (β = 1.345±0.5015, Pperm = 0.02); и с увеличением стационарной пространственной скорости роста сгустка: rs11183780 CCHCR1 (β = 14,36±6,5, Pperm = 0,03). Таким образом, ИБС модифицирует ассоциации между биохимическими маркерами и GWAS-значимыми локусами у больных с тяжелой формой COVID-19.

Severe COVID-19, including hospitalization and mortality, is determined by both genetic risk factors and concomitant chronic diseases, among which coronary artery disease (CAD) plays a leading role. The aim of this study was to evaluate the impact of CAD on the associations between biochemical markers of patients with severe COVID-19 and GWAS-significant loci. Genotyping of 199 patients hospitalized with severe COVID-19 was carried out by PCR for 10 GWAS loci. In the presence of concomitant CAD in patients with severe COVID-19, polymorphic variants were associated with an increase in plasma fibrinogen: rs12610495 DPP9 (β = 1.528±0.5637, Pperm = 0.02), rs7949972 ELF5 (β = 1.345±0.5015, Pperm = 0.02), rs61882275 ELF5 (β = 1.345±0.5015, Pperm = 0.02); and with an increase in the steadystate spatial clot growth rate: rs11183780 CCHCR1 (β = 14.36±6.5, Pperm = 0.03). Thus, CAD modifies associations between biochemical markers and GWAS-significant loci in patients with severe COVID-19.

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The authors declare that there are no conflicts of interest present.