A multilevel model for assessing the risk of prereproductive mortality of offspring in human populations

Abstract

The model imitating the processes (transmission in a series of generations) and variability (mutational and combinational) of genes that determine a multifactorial trait («pre-productive death of offspring») in a population. The model uses a normal distribution to estimate the probability of pre–productive death of offspring at various stages of the implementation of a genotype into a phenotype (a gene as a DNA reading chain – chromosome – organism – population). The model allows us to obtain prognostic estimates of the survival of a human population in a given number of generations, taking into account the segregation burden, the risk of new gene mutations, and other environmental factors.