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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25557/2073-7998.2025.11.70-73</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-3304</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКОЕ СООБЩЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Многоуровневая модель оценки риска дорепродуктивной гибели потомства в популяциях человека</article-title><trans-title-group xml:lang="en"><trans-title>A multilevel model for assessing the risk of prereproductive mortality of offspring in human populations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гиневский</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ginevskiy</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>123098, Москва, ул. Живописная, д.46</p></bio><bio xml:lang="en"><p>46, Zhivopisnaya st., Moscow, 123098</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ижевский</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Izhevskiy</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>123098, Москва, ул. Живописная, д.46</p></bio><bio xml:lang="en"><p>46, Zhivopisnaya st., Moscow, 123098</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Государственный научный центр Российской Федерации – Федеральный медицинский биофизический центр имени А.И. Бурназяна ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Center – Burnasyan Federal Medical Biophysical Center Federal Medical-Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2025</year></pub-date><volume>24</volume><issue>11</issue><fpage>70</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гиневский Д.А., Ижевский П.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гиневский Д.А., Ижевский П.В.</copyright-holder><copyright-holder xml:lang="en">Ginevskiy D.A., Izhevskiy P.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/3304">https://www.medgen-journal.ru/jour/article/view/3304</self-uri><abstract><p>Предложена модель, имитирующая процессы наследственности (передачи в ряду поколений) и изменчивости (мутационной и комбинационной) генов, детерминирующих мультифакториальный признак (дорепродуктивную гибель потомства) в популяции. В модели используется нормальное распределение для оценки вероятности дорепродуктивной гибели потомства на различных этапах реализации генотипа в фенотип (ген – хромосома – организм – популяция). Модель позволяет получить прогностические оценки выживания популяции человека в заданном ряду поколений с учетом сегрегационного груза, риска новых генных мутаций и влияния факторов окружающей среды.</p></abstract><trans-abstract xml:lang="en"><p>The model imitating the processes (transmission in a series of generations) and variability (mutational and combinational) of genes that determine a multifactorial trait («pre-productive death of offspring») in a population. The model uses a normal distribution to estimate the probability of pre–productive death of offspring at various stages of the implementation of a genotype into a phenotype (a gene as a DNA reading chain – chromosome – organism – population). The model allows us to obtain prognostic estimates of the survival of a human population in a given number of generations, taking into account the segregation burden, the risk of new gene mutations, and other environmental factors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>моделирование</kwd><kwd>геном</kwd><kwd>мутации</kwd><kwd>поколения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>modeling</kwd><kwd>genome</kwd><kwd>mutations</kwd><kwd>generations</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено без внешнего финансирования</funding-statement><funding-statement xml:lang="en">The study was conducted without external funding</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">https://www.ncbi.nlm.nih.gov, 03.03.2025</mixed-citation><mixed-citation xml:lang="en">https://www.ncbi.nlm.nih.gov, 03.03.2025</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
