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Search for genetic markers of ischemic stroke by studying of human orthologues of rat genes expressed differentially in experimental brain ischemia
https://doi.org/10.25557/2073-7998.2025.10.139-141
Abstract
Although several dozen genetic loci have been associated with ischemic stroke, they describe only about 2% of the phenotypic variability in patients, indicating the potential for identifying additional genetic factors. The paper summarizes the results of applying our technology for processing transcriptomic data obtained under conditions of modeling cerebral stroke in rats to search for candidate genes associated with ischemic stroke in humans.
Supporting agencies: The work was carried out within the state assignment of NRC «Kurchatov Institute» (consolidation of research results) and with financial support of the Russian Science Foundation, grant number 23-14-00131 (bioinformatic analysis).
About the Authors
A. V. Khrunin
National Research Centre «Kurchatov Institute»
Russian Federation
Russian Federation
2, Akademika Kurchatova sq., Moscow, 123182
G. V. Khvorykh
National Research Centre «Kurchatov Institute»
Russian Federation
Russian Federation
2, Akademika Kurchatova sq., Moscow, 123182
S. A. Limborska
National Research Centre «Kurchatov Institute» ; Research Centre for Medical Genetics
Russian Federation
Russian Federation
2, Akademika Kurchatova sq., Moscow, 123182
1, Moskvorechye st, Moscow,115522
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Review
For citations:
Khrunin A.V., Khvorykh G.V., Limborska S.A. Search for genetic markers of ischemic stroke by studying of human orthologues of rat genes expressed differentially in experimental brain ischemia. Medical Genetics. 2025;24(10):139-141. (In Russ.) https://doi.org/10.25557/2073-7998.2025.10.139-141
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