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Gender-specific associations of polymorphic variant rs8140505 of the GGT5 gene with the risk of ischemic stroke in residents of Central Russia
https://doi.org/10.25557/2073-7998.2025.10.77-79
Abstract
Background. Since oxidative stress plays a role in the pathogenesis of ischemic stroke (IS), it is important to investigate the molecular mechanisms contributing to redox homeostasis and glutathione metabolism.
Aim: to analyze the association of the rs8140505 polymorphism of gamma-glutamyltransferase 5 (GGT5) gene with the risk of ischemic stroke.
Methods. DNA samples from 600 patients with IS and 688 controls were used for genotyping SNP rs8140505 by real-time PCR with allele discrimination using TaqMan probes.
Results. It was found that genotypes -G/G are associated with an increased risk of IS in females of Central Russia (OR=2,51, 95%CI 1,17– 5,36, Pperm=0,034), while no associations between rs 8140505 genotypes were observed in males.
Conclusion. This study was the first to establish the association of the rs8140505 polymorphism with the risk of IS. Further studies are needed to clarify the nature of the sex-specific SNP association.
Keywords
Supporting agencies: This work was financially supported by Kursk State Medical University.
About the Author
E. L. Drozdova
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, Karl Marx st., Kursk, 305041
References
1. Moskalenko M.I., Ponomarenko I.V., Polonikov A.V., et al. The role of stress factors and genetic predisposition in the development of stroke in patients with essential hypertension. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2019; 119(3. Vyp. 2):11-17. DOI 10.17116/jnevro201911903211.
2. Guliyeva S.V., Ismailova A.T. Rol’ okislitel’nogo stressa, mitokhondrial’noy disfunktsii i apoptoza v ostrom periode ishemicheskogo insul’ta [The role of oxidative stress, mitochondrial dysfunction and apoptosis in the acute period of ischemic stroke]. Vestnik nauki i obrazovaniya [Bulletin of Science and Education]. 2017; 10 (34): 73-76. (In Russ.)
3. Bocharova Yu.A. Issledovaniye assotsiatsiy trokh polimorfnykh variantov gena glutationsintazy (GSS) c riskom razvitiya ishemicheskogo insul’ta [Investigation of associations of three polymorphic variants of the glutathione synthetase (GS) gene with the risk of ischemic stroke]. Nauchnyye rezul’taty biomeditsinskikh issledovaniy [Scientific results of biomedical research]. 2020; 6(4):476- 487. DOI:10.18413/2658-6533-2020-6-4-0-4. (In Russ.)
4. Polonikov A., Rymarova L., Klyosova E., et al. Matrix metalloproteinases as target genes for gene regulatory networks driving molecular and cellular pathways related to a multistep pathogenesis of cerebrovascular disease. Journal of Cellular Biochemistry. 2019; 120(10):16467-16482. DOI: 10.1002/jcb.28815.
Review
For citations:
Drozdova E.L. Gender-specific associations of polymorphic variant rs8140505 of the GGT5 gene with the risk of ischemic stroke in residents of Central Russia. Medical Genetics. 2025;24(10):77-79. (In Russ.) https://doi.org/10.25557/2073-7998.2025.10.77-79
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