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Polymorphisms of the gamma-glutamyltransferase 1 (GGT1) gene and ischemic heart disease: association with predisposition and lesions of coronary arteries
https://doi.org/10.25557/2073-7998.2025.10.72-74
Abstract
The aim of this study was to investigate the relationship between four functionally significant single nucleotide polymorphisms (SNPs) – rs2236626, rs5751901, rs5760492, and rs28509371 of the GGT1 gene and the development of coronary heart disease (CHD). A comparative analysis of the allele and genotype frequencies of the SNPs rs2236626, rs5751901, rs28509371 among patients with CHD and controls did not reveal statistically significant associations with the development of CHD, both in the overall groups and in the groups stratified by gender (P>0.05). Furthermore, an analysis of metric data assessing the degree of coronary artery stenosis indicated that polymorphisms of the GGT1 gene are associated with a lesser degree of damage to individual coronary arteries, as well as more favorable physiological parameters of myocardial contractility.
Keywords
ischemic heart disease,
hereditary predisposition,
glutathione metabolism,
gamma-glutamyltransferase 1,
single nucleotide polymorphism (SNP)
Supporting agencies: The work was carried out with the financial support of the Russian Science Foundation (project No. 25-25-20086) and the Ministry of Education and Science of the Kursk Region.
About the Authors
M. F. Grigoryan
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
S. I. Kononov
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
E. L. Drozdova
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
A. A. Polonikova
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
Iu. E. Azarova
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
O. Yu. Bushueva
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
A. V. Polonikov
Kursk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, K. Marx st, Kursk, 305041
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Review
For citations:
Grigoryan M.F., Kononov S.I., Drozdova E.L., Polonikova A.A., Azarova I.E., Bushueva O.Yu., Polonikov A.V. Polymorphisms of the gamma-glutamyltransferase 1 (GGT1) gene and ischemic heart disease: association with predisposition and lesions of coronary arteries. Medical Genetics. 2025;24(10):72-74. (In Russ.) https://doi.org/10.25557/2073-7998.2025.10.72-74
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