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Methylation status of the promoter regions of the XRCC1, XRCC2, XRCC3, XRCC4 genes in workers of coal-fired thermal power plants
https://doi.org/10.25557/2073-7998.2025.09.73-74
Abstract
It is known that in the atmosphere of coal production a number of carcinogenic factors arise that cause a negative impact on the genetic stability. In this regard, it is necessary to determine genotoxic effects in workers of coal-fired thermal power plants. The work studied the influence of the production environment of coal-fired thermal power plants on the epigenetic regulation of the XRCC1, XRCC2, XRCC3, XRCC4 genes in 455 workers of coal-fired thermal power plants in the city of Kemerovo compared with 533 non-working residents of the same region. The methylation status of the promoters of the studied genes was assessed using methyl-specific polymerase chain reaction. The influence of the industrial environment on the change in the effect of methylation of the promoters of all studied genes in producers was established.
Supporting agencies: The study was not supported by sponsorship.
About the Author
A. V. Marushchak
Federal Research Center for Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
18, Sovetsky Ave., Kemerovo, 650000
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Review
For citations:
Marushchak A.V. Methylation status of the promoter regions of the XRCC1, XRCC2, XRCC3, XRCC4 genes in workers of coal-fired thermal power plants. Medical Genetics. 2025;24(9):73-74. (In Russ.) https://doi.org/10.25557/2073-7998.2025.09.73-74
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