medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2025.09.73-74medgen-3180Research ArticleКРАТКОЕ СООБЩЕНИЕBRIEF REPORTИзучение статуса метилирования промоторных областей генов XRCC1, XRCC2, XRCC3, XRCC4 у работников угольных теплоэлектростанцийMethylation status of the promoter regions of the XRCC1, XRCC2, XRCC3, XRCC4 genes in workers of coal-fired thermal power plantsМарущакА. В.MarushchakA. V.

650000, г. Кемерово, пр-т Советский, д. 18

18, Sovetsky Ave., Kemerovo, 650000

marushchak.av@mail.ruФГБНУ Федеральный исследовательский центр угля и углехимии Сибирского отделения Российской академии наукРоссияFederal Research Center for Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of SciencesRussian Federation2025131120252497374Copyright © Марущак А.В., 20252025Марущак А.В.Marushchak A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/3180

Известно, что в воздухе угольного производства содержится целый ряд канцерогенных соединений, оказывающих негативное воздействие на генетическую стабильность. В связи с этим необходимо определить генотоксические эффекты у работников угольных теплоэлектростанций. В работе изучено влияние производственной среды на эпигенетическую регуляцию генов XRCC1, XRCC2, XRCC3, XRCC4 у 455 работников угольных теплоэлектростанций г. Кемерово по сравнению с 533 неработающими на производстве жителями той же области. Оценка статуса метилирования промоторов изучаемых генов проводилась с использованием метил-специфической полимеразной цепной реакции. Установлено влияние промышленной среды на изменение статуса метилирования промоторов всех изучаемых генов у работников.

It is known that in the atmosphere of coal production a number of carcinogenic factors arise that cause a negative impact on the genetic stability. In this regard, it is necessary to determine genotoxic effects in workers of coal-fired thermal power plants. The work studied the influence of the production environment of coal-fired thermal power plants on the epigenetic regulation of the XRCC1, XRCC2, XRCC3, XRCC4 genes in 455 workers of coal-fired thermal power plants in the city of Kemerovo compared with 533 non-working residents of the same region. The methylation status of the promoters of the studied genes was assessed using methyl-specific polymerase chain reaction. The influence of the industrial environment on the change in the effect of methylation of the promoters of all studied genes in producers was established.

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The authors declare that there are no conflicts of interest present.