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Genetic determinants of involvement of a new class of proteins with chaperone activity (Hero) in the risk and clinical manifestations of ischemic stroke
https://doi.org/10.25557/2073-7998.2025.09.32-33
Abstract
Proteins with chaperone properties play an important role both in the risk of developing ischemic stroke (IS) and in protecting cells under ischemic conditions. The aim of this work was to analyze the associations of polymorphic variants of the Hero genes (SERBP1, SERF2, C19orf53, C11orf58, C9orf16) with the risk of developing and clinical manifestations of IS. It was found that the association of Hero SNPs with IS is characterized by sex-specific effects and is also significantly modulated by environmental risk factors. Functional annotation of SNPs showed that the molecular mechanisms of the association of Hero genes with IS are due to their participation in the regulation of neuro- and angiogenesis, apoptosis, oxidative stress, hypoxia and inflammation.
Supporting agencies: The study was supported by the Russian Science Foundation (project No. 22-15-00288).
About the Authors
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
K. A. Kobzeva
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
I. V. Shilenok
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
References
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3. Tsuboyama K., Osaki T., Matsuura-Suzuki E., et al. A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PLoS Biol. 2020;18(3):e3000632. doi:10.1371/journal.pbio.3000632
Review
For citations:
Bushueva O.Yu., Kobzeva K.A., Shilenok I.V. Genetic determinants of involvement of a new class of proteins with chaperone activity (Hero) in the risk and clinical manifestations of ischemic stroke. Medical Genetics. 2025;24(9):32-33. (In Russ.) https://doi.org/10.25557/2073-7998.2025.09.32-33
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