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Association study of polymorphisms of the glutathione s-transferase alpha 4 (GSTA4) gene and the risk of psoriasis: a pilot study
https://doi.org/10.25557/2073-7998.2025.08.112-113
Abstract
The aim of this pilot study was to investigate the associations between polymorphic variants of the GSTA4 gene and the risk of psoriasis.
The study involved 474 patients with psoriasis and 470 controls, whose DNA samples were genotyped for the variants rs7496, rs17614871, rs12524274, rs316133, and rs2274760 of the GSTA4 gene using the MassArray-4 system. No statistically significant associations were found between these variants and the predisposition to the disease, either when comparing the overall groups or when stratifying by sex (p > 0.05). However, the GSTA4 CACCG haplotype was identified, which was associated with a decreased risk of psoriasis in men (pperm = 0.004). Although the studied variants of the GSTA4 gene do not exhibit individual effects on the risk of developing psoriasis, the relatively rare CACCG haplotype demonstrated a protective effect against the disease.
Keywords
psoriasis,
hereditary predisposition,
biotransformation of xenobiotics,
glutathione S-transferase alpha 4,
single nucleotide polymorphism
Supporting agencies: The study had no sponsorship
About the Authors
R. V. Saranyuk
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
E. V. Efanova
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
A. A. Polonikova
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
M. A. Solodilova
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st.; Kursk
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Review
For citations:
Saranyuk R.V., Bushueva O.Yu., Efanova E.V., Polonikova A.A., Solodilova M.A., Polonikov A.V. Association study of polymorphisms of the glutathione s-transferase alpha 4 (GSTA4) gene and the risk of psoriasis: a pilot study. Medical Genetics. 2025;24(8):112-113. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.112-113
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