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Identification of hereditary forms of morbid obesity in children
https://doi.org/10.25557/2073-7998.2025.08.106-109
Abstract
Given the important role of obesity in the development of metabolic disorders, identifying pathogenic gene variants in children with severe obesity is a key task of endocrinology. Whole exome sequencing (WES) was performed in 59 children with morbid obesity and 30 variants were found in 16 genes that were clinically significant in 23 children, which amounted to 38.9% of the total sample, more than half of them were identified for the first time. The results of the study expand the understanding of the genetic structure of obesity in the Russian population.
Supporting agencies: The study was not supported by sponsorship
About the Authors
R. R. Salakhov
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
D. A. Kopytina
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
R. I. Khusainova
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
O. V. Vasyukova
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
R. M. Guseynova
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
V. A. Peterkova
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
I. R. Minniakhmetov
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
N. G. Mokrysheva
I.I. Dedov National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
117292; 11, Dm.Ulyanova st.; Moscow
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Review
For citations:
Salakhov R.R., Kopytina D.A., Khusainova R.I., Vasyukova O.V., Guseynova R.M., Peterkova V.A., Minniakhmetov I.R., Mokrysheva N.G. Identification of hereditary forms of morbid obesity in children. Medical Genetics. 2025;24(8):106-109. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.106-109
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