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Cytokines levels as an inflammation markers in autoinflammatory diseases
https://doi.org/10.25557/2073-7998.2025.08.48-51
Abstract
Familial Mediterranean fever (FMF) is an autoinflammatory disease manifested by recurrent fever with signs of systemic inflammation caused by MEFV gene pathogenic variants that lead to inflammasome hyperactivation and hyperproduction of IL-1b and IL-18. FMF is a disorder with variable expressivity and penetrance. The study included 1336 samples, 1271 samples were positive for pathogenic variants in MEFV gene. 160 samples divided into 3 groups: 95 patients (FMF) with different MEFV genotypes (5 subgroups), 49 patients with systemic lupus erythematosus (SLE) and 16 samples as a group of healthy donors (HD). Concentrations of CRP, IL-6, IL-8 and IL-18 were measured for all samples. Concentrations of CRP, IL-6 and IL-18 in FMF group was significantly higher than in HD and SLE groups (р < 0.0001). Concentration of IL-18 was significantly higher in all FMF genotypes subgroups than in HD. Comparing IL-18 levels between different pathogenic MEFV variants samples with «aggressive» variants (p.Met694Val and p.Met680Ile) characterized by increased concentration of IL-18 (р = 0.0411).
Supporting agencies: The study was not supported by sponsorship
About the Authors
E. A. Deviatkina
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
197101; 6/8, L.Tolstogo st.; St. Petersburg
V. D. Nazarov
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
197101; 6/8, L.Tolstogo st.; St. Petersburg
A. K. Musonova
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
197101; 6/8, L.Tolstogo st.; St. Petersburg
S. V. Lapin
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
197101; 6/8, L.Tolstogo st.; St. Petersburg
I. V. Kholopova
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
197101; 6/8, L.Tolstogo st.; St. Petersburg
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Review
For citations:
Deviatkina E.A., Nazarov V.D., Musonova A.K., Lapin S.V., Kholopova I.V. Cytokines levels as an inflammation markers in autoinflammatory diseases. Medical Genetics. 2025;24(8):48-51. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.48-51
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