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The LZTFL1 gene polymorphic variant rs73064425 correlation with clinical and laboratory parameters in patients with novel coronavirus infection
https://doi.org/10.25557/2073-7998.2025.08.46-47
Abstract
Assessment of clinical and laboratory parameters plays an important role in predicting the severity of COVID-19. At the same time, the genetic markers identification will allow for the earliest stratification of patients by severe infection risk groups. We have genotyped 118 patients with moderate and severe forms of novel coronavirus infection by rs73064425 of the LZTFL1 gene associated with the COVID-19 severity. Based on the data obtained, a replicative analysis of the polymorphic variant rs73064425 association with the developing severe COVID-19 risk in the Russian population was performed. The correlation of this marker with clinical and laboratory parameters was also analyzed. Statistically significant differences were found between groups of patients with varying degrees of severity in the T allele. CT genotype was statistically significantly associated with thrombocytopenia, decreased white blood cell count and decreased blood saturation.
Supporting agencies: The research was carried out at the expense of the State assignment (fundamental scientific research No. 122020200083-8)
About the Authors
A. A. Gusarova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
R. A. Korneeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
A. A. Babovskaya
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
M. M. Gavrilenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
I. D. Bespalova
Siberian State Medical University
Russian Federation
Russian Federation
634050; 2, Moscowski Trakt; Tomsk
A. V. Teteneva
Siberian State Medical University
Russian Federation
Russian Federation
634050; 2, Moscowski Trakt; Tomsk
O. V. Zhilyakova
Siberian State Medical University
Russian Federation
Russian Federation
634050; 2, Moscowski Trakt; Tomsk
T. V. Gabidulina
Siberian State Medical University
Russian Federation
Russian Federation
634050; 2, Moscowski Trakt; Tomsk
S. Yu. Yuryev
Siberian State Medical University
Russian Federation
Russian Federation
634050; 2, Moscowski Trakt; Tomsk
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation
Russian Federation
634050; 10, Nab. Ushaiki; Tomsk
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Review
For citations:
Gusarova A.A., Korneeva R.A., Trifonova E.A., Bocharova A.V., Babovskaya A.A., Gavrilenko M.M., Bespalova I.D., Teteneva A.V., Zhilyakova O.V., Gabidulina T.V., Yuryev S.Yu., Stepanov V.A. The LZTFL1 gene polymorphic variant rs73064425 correlation with clinical and laboratory parameters in patients with novel coronavirus infection. Medical Genetics. 2025;24(8):46-47. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.46-47
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