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Transcriptome analysis of brain cells in animal models under ischemic injury and the action of peptide drugs
https://doi.org/10.25557/2073-7998.2025.07.112-113
Abstract
Using Wistar rats, as well as transcriptomics and fundamental medicine methods, the features of gene function in the brain were studied during cerebral ischemia in animals and under the influence of peptide drugs with neuroprotective properties.
Keywords
transcriptome,
non-coding RNAs,
ischemic stroke,
rat model of cerebral ischemia,
peptide drugs,
neuroprotection
Supporting agencies: The work was carried out within the state assignment of NRC «Kurchatov Institute» (bioinformatics data processing) and with financial support of the Russian Science Foundation (RSF), grant number 24-14-00027, https://rscf.ru/project/24-14-00027/ (analysis of gene expression).
About the Authors
I. B. Filippenkov
National Research Centre «Kurchatov Institute»
Russian Federation
Russian Federation
1, Kurchatov sq., Moscow, 123182
L. V. Dergunova
National Research Centre «Kurchatov Institute»
Russian Federation
Russian Federation
1, Kurchatov sq., Moscow, 123182
N. F. Myasoedov
National Research Centre «Kurchatov Institute»
Russian Federation
Russian Federation
1, Kurchatov sq., Moscow, 123182
S. A. Limborska
National Research Centre «Kurchatov Institute»;
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Kurchatov sq., Moscow, 123182;
1, Moskvorechye st., Moscow, 115522
References
1. Bevan S., Traylor M., Adib-Samii P., et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke 2012; 43:3161–3167.
2. Dergunova L.V., Filippenkov I.B., Limborska S.A., Myasoedov N.F. Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries. Genes (Basel). 2023; 14:953.
3. Filippenkov I.B., Sudarkina O.Y., Limborska S.A., Dergunova L.V. Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues. RNA Biol. 2015; 12: 1030–1042.
Review
For citations:
Filippenkov I.B., Dergunova L.V., Myasoedov N.F., Limborska S.A. Transcriptome analysis of brain cells in animal models under ischemic injury and the action of peptide drugs. Medical Genetics. 2025;24(7):112-113. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.112-113
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