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Analysis of the association between SELP gene polymorphism and the risk of first-trimester pregnancy loss in women from the Rostov region
https://doi.org/10.25557/2073-7998.2025.07.104-106
Abstract
Introduction. Miscarriage remains a significant problem in modern obstetrics, affecting 10-25% of all pregnancies. Cell adhesion molecules play a key role in the reproductive cycle, and their changes can lead to reproductive pathologies.
Aim: to study the association of the rs6131 (1057C>T, S290N) polymorphism of the SELP gene with the risk of miscarriage in the first trimester in women of the Rostov region.
Methods. The study used DNA samples obtained from the blood of 114 women (59 – control group – women with a physiological course of pregnancy, 55 – women with miscarriage (25 – with spontaneous abortion, 30 – with an undeveloped pregnancy)). DNA was isolated by thermocoagulation; nucleotide substitutions were determined by allele-specific PCR.
Results. The frequency of homozygotes for the C allele was 66.1% in the control group and 60% in the miscarriage group. The frequency distribution of genotypes and alleles according to rs6131 did not differ between the groups of women (p > 0.05).
Conclusions. The rs6131 polymorphism is not associated with a change in the risk of miscarriage in the first trimester.
Supporting agencies: The work was carried out with the financial support of the Ministry of Science and Higher Education of the Russian Federation within the framework of the state assignment in the field of scientific activity No. FENW-2023-0018.
About the Authors
T. A. Sukhodolova
Southern federal university (SFedU), D. I. Ivanovsky Academy of Biology and Biotechnology
Russian Federation
Russian Federation
194/1 Stachki Avenue, Rostov-on-Don, 344090
E. V. Mashkina
Southern federal university (SFedU), D. I. Ivanovsky Academy of Biology and Biotechnology
Russian Federation
Russian Federation
194/1 Stachki Avenue, Rostov-on-Don, 344090
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Review
For citations:
Sukhodolova T.A., Mashkina E.V. Analysis of the association between SELP gene polymorphism and the risk of first-trimester pregnancy loss in women from the Rostov region. Medical Genetics. 2025;24(7):104-106. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.104-106
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