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Key genes and signaling pathways underlying infective endocarditis: results of whole transcriptome sequencing
https://doi.org/10.25557/2073-7998.2025.07.97-99
Abstract
Here the results of wholes transcriptome sequencing of infective endocarditis (IE) affected native heart valves are presented. Resulting to the study, the differentially expressed genes and some signaling pathways underlaying IE pathogenesis have been described.
Supporting agencies: This research was supported by the Russian Science Foundation (Grant No. 23-75-10020) «Molecular genetic basis of the pathogenesis of infective endocarditis in native and bioprosthetic heart valves», https://rscf.ru/project/23-75-10020/.
About the Authors
A. V. Sinitskaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
A. E. Kostyunin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
M. V. Khutornaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
M. A. Asanov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
A. O. Poddubnyak
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
A. E. Tupikin
Institute of Сhemical Biology and Fundamental Medicine of the Siberian Branch of the RAS
Russian Federation
Russian Federation
8, Ac. Lavrentieva ave., Novosibirsk, 630090
M. R. Kabilov
Institute of Сhemical Biology and Fundamental Medicine of the Siberian Branch of the RAS
Russian Federation
Russian Federation
8, Ac. Lavrentieva ave., Novosibirsk, 630090
M. Yu. Sinitsky
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
References
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2. Yi C., Zhang H., Yang J., et al. Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing. Front Immunol. 2024;14:1298041. doi: 10.3389/fimmu.2023.1298041.
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Review
For citations:
Sinitskaya A.V., Kostyunin A.E., Khutornaya M.V., Asanov M.A., Poddubnyak A.O., Tupikin A.E., Kabilov M.R., Sinitsky M.Yu. Key genes and signaling pathways underlying infective endocarditis: results of whole transcriptome sequencing. Medical Genetics. 2025;24(7):97-99. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.97-99
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