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GWAS-significant uterine fibroid locus rs66998222 LOC102723323 is associated with the risk of benign ovarian tumors
https://doi.org/10.25557/2073-7998.2025.07.82-83
Abstract
Uterine fibroids (UF) and benign ovarian tumors (BOTs) are characterized by common risk factors that affect the level of sex hormones; however, the common genetic component of these diseases is poorly understood.
The aim of the study was to investigate the association of GWAS-significant UF loci with the risk of BOTs development against the background of UF.
Materials: genotyping of 654 DNA samples of UF patients (including 59 with comorbid BOTs) was performed by real-time PCR.
Results: SNP rs66998222 LOC102723323 G/A is associated with a reduced risk of BOTs (OR = 0.47, 95% CI = 0.27-0.85, p = 0.006).
Conclusions: Bioinformatics analysis showed that SNP rs66998222 LOC102723323 may be associated with the risk of BOTs through involvement in the regulation of cytokine pathways, inflammation, obesity, and age at menarche.
Supporting agencies: The study was funded by the Kursk State Medical University.
About the Author
L. A. Ponomareva
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
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Review
For citations:
Ponomareva L.A. GWAS-significant uterine fibroid locus rs66998222 LOC102723323 is associated with the risk of benign ovarian tumors. Medical Genetics. 2025;24(7):82-83. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.82-83
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